THE CHRONOBIOLOGICAL HYPOTHESIS AND PSYCHOSOCIAL AND CULTURAL GENOMIC THERAPIES: FROM THE EXAMPLE OF PARKINSON’S DISEASE AND NEURODEGENERATIVE PROCESS

Recent research on Parkinson’s Disease (PD) revealed some common etiopathogenic mechanisms underlying a large range of chronic diseases, and more specifically the deregulation of chronobiological rhythms that may start in the very beginning of such pathological development. Contrary to the bottom-up tradition, the post-genomic biology provides now a much favorable zeitgeist to integrate holistic interventions in both biomedical research and mainstream medical practice. Such integrative efforts may not only improve our understanding of system-level dynamics about health and disease, but also opens larger possibilities for new clinical options that bring positive pathological evolutions while globally increasing quality of life of patients, caregivers, and their families. To facilitate the transition, we renew the invitation to join our international open source research project in widely testing the Creative Psychosocial Genomic Healing Experience (CPGHE), an evidence-based construction of a holistic and naturalist intervention with its standardized version specially designed to offer easy adaption for scientific investigation towards an evidence-based integration of holistic intervention possibilities

Exploring how practitioners support and protect adults at risk of harm in the light of the Adult Support and Protection (Scotland) Act 2007

This was a joint academic and practitioner research project that interviewed practitioners and people about their experience of assessment and intervention under the Adult Support and Protection (Scotland) Act 2007. Findings include: the complex and interconnected nature of harm, the value of skilled and open minded practitioners, the need to build and maintain respectful relationships; that thresholds not as clear cut as we might like them to be, protecting means supporting, interagency work was variable in its quality and opportunities for justice through court might still be limite

Validation of the delinquent activities scale for incarcerated adolescents

Purpose: This study examined the validity of the Delinquent Activities Scale (DAS), based in part on the Self Reported Delinquency (SRD) scale. Method: Participants were 190 incarcerated adolescents (85.8% male; average age 17 years) at a juvenile correctional facility in the Northeast. While incarcerated, they were asked about substance use and delinquent activities in the 1 year prior to incarceration, as well as parental, peer, and demographic information. They were tracked at three months post-release, given the DAS, and assessed for post-release substance use. Results: Three factors of the DAS assess general, alcohol-involved, and marijuana-involved delinquent activities. Principal components analysis was used to develop subscales within each factor. Support was found for concurrent and predictive incremental validities of these factors and their subscales in predicting substance use, with stronger findings for the general and the alcohol-involved factors. Subscales related to stealing showed lower validity than those related to more aggressive behaviors. Conclusions: These analyses suggest that the factors and empirically derived subscales offer researchers and clinicians a psychometrically sound approach for the assessment of adolescent misbehaviors

The Economic Resource Receipt of New Mothers

U.S. federal policies do not provide a universal social safety net of economic support for women during pregnancy or the immediate postpartum period but assume that employment and/or marriage will protect families from poverty. Yet even mothers with considerable human and marital capital may experience disruptions in employment, earnings, and family socioeconomic status postbirth. We use the National Survey of Families and Households to examine the economic resources that mothers with children ages 2 and younger receive postbirth, including employment, spouses, extended family and social network support, and public assistance. Results show that many new mothers receive resources postbirth. Marriage or postbirth employment does not protect new mothers and their families from poverty, but education, race, and the receipt of economic supports from social networks do

Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.

C9ORF72 mutations are found in a significant fraction of patients suffering from amyotrophic lateral sclerosis and frontotemporal dementia, yet the function of the C9ORF72 gene product remains poorly understood. We show that mice harboring loss-of-function mutations in the ortholog of C9ORF72 develop splenomegaly, neutrophilia, thrombocytopenia, increased expression of inflammatory cytokines, and severe autoimmunity, ultimately leading to a high mortality rate. Transplantation of mutant mouse bone marrow into wild-type recipients was sufficient to recapitulate the phenotypes observed in the mutant animals, including autoimmunity and premature mortality. Reciprocally, transplantation of wild-type mouse bone marrow into mutant mice improved their phenotype. We conclude that C9ORF72 serves an important function within the hematopoietic system to restrict inflammation and the development of autoimmunity

Evaluation Research and Institutional Pressures: Challenges in Public-Nonprofit Contracting

This article examines the connection between program evaluation research and decision-making by public managers. Drawing on neo-institutional theory, a framework is presented for diagnosing the pressures and conditions that lead alternatively toward or away the rational use of evaluation research. Three cases of public-nonprofit contracting for the delivery of major programs are presented to clarify the way coercive, mimetic, and normative pressures interfere with a sound connection being made between research and implementation. The article concludes by considering how public managers can respond to the isomorphic pressures in their environment that make it hard to act on data relating to program performance.This publication is Hauser Center Working Paper No. 23. The Hauser Center Working Paper Series was launched during the summer of 2000. The Series enables the Hauser Center to share with a broad audience important works-in-progress written by Hauser Center scholars and researchers